Significance of coagulation and fibrinolysis markers for benign and malignant soft tissue tumors
نویسندگان
چکیده
Abstract Background The intimate relationship between coagulation and fibrinolysis in malignant tumors is a well-known phenomena, with the phenotype enhancing fibrinolysis. We hypothesized that soft tissue sarcoma (STS) affects expression of markers, which could be used to distinguish STS from benign tumors. analyzed correlations plasma levels D-dimer (DD), plasmin-α2 plasmin inhibitor complex (PIC), soluble fibrin (SF), thrombin-antithrombin III (TAT) elucidate whether these markers can predict STS. Methods Plasma DD, PIC, SF TAT primary (benign 67, 68) were measured before biopsy or treatment. marker compared various clinicopathological parameters. Results In malignancy (STS), average PIC significantly higher than Multivariate logistic analysis continuous variables indicated only exhibited significant difference (OR: 24.5, 95%CI: 3.55–170, p = 0.0012). Receiver operating characteristic curve produced area under values for DD: 0.691, PIC: 0.784, SF: 0.734 TAT: 0.588. Youden’s index was establish thresholds 0.37 0.80 0.90 (SF) 0.82 (TAT). Threshold high specificity (0.881, 0.791) positive predictive value (0.818, 0.745), respectively. highest accuracy among observed (0.704). Significant differences multivariate binary demonstrated by categorizing low groups based on their threshold, (≥0.80) 3.36, 1.19–9.43, 0.0212) (≥0.90) 2.63, 1.04–6.66, 0.0404) . Conclusions Of studied, increased related over most suitable prediction STS, which, along other diagnostic tools, represents helpful subsidiary tool
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ژورنال
عنوان ژورنال: BMC Cancer
سال: 2021
ISSN: ['1471-2407']
DOI: https://doi.org/10.1186/s12885-021-08091-1